ComGD

• Description: DNA transport machinery, minor pseudopilin
  
  

Gene name	comGD
Synonyms
Essential	no
Product	minor pseudopilin
Function	genetic competence, DNA uptake
Gene expression levels in SubtiExpress: comGD
Interactions involving this protein in SubtInteract: ComGD
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	15 kDa, 9.883
Gene length, protein length	429 bp, 143 aa
Immediate neighbours	comGE, comGC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

• Locus tag: BSU24700

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • ComGB-ComGD PubMed
  • ComC-ComGD PubMed
  • ComGD-ComGG PubMed
  • ComGD-ComGE PubMed

• Localization:
  • associated to the membrane via ComGG PubMed
  • cell surface PubMed

Database entries

• Structure:

• UniProt: P25956

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: comGA-comGB-comGC-comGD-comGE-comGF-comGG-yqzE PubMed

• Expression browser: comGD PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by casamino acids PubMed

• Regulatory mechanism:
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159] [WorldCat.org] [DOI] (P p)