HtrB

From SubtiWiki
Revision as of 12:38, 7 January 2014 by 134.76.70.252 (talk)
Jump to: navigation, search
  • Description: membrane-anchored protein quality control protease, serine protease, response to secretion and heat stresses

Gene name htrB
Synonyms yvtA, yvtB
Essential no
Product serine protease
Function protein quality control
Gene expression levels in SubtiExpress: htrB
Metabolic function and regulation of this protein in SubtiPathways:
htrB
MW, pI 48 kDa, 4.632
Gene length, protein length 1374 bp, 458 aa
Immediate neighbours mrgA, cssR
Sequences Protein DNA DNA_with_flanks
Genetic context
YvtA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HtrB expression.png



















Categories containing this gene/protein

proteolysis, heat shock proteins, membrane proteins

This gene is a member of the following regulons

CssR regulon

The gene

Basic information

  • Locus tag: BSU33000

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: peptidase S1B family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:
    • cell membrane (according to Swiss-Prot)
    • randomly distributed in foci throughout the cell surface PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: htrB (according to DBTBS)
  • Sigma factor:
  • Regulation:
    • expressed under conditions of secretion stress (CssR) PubMed
    • induced by rhamnolipids PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Ross E Dalbey, Peng Wang, Jan Maarten van Dijl
Membrane proteases in the bacterial protein secretion and quality control pathway.
Microbiol Mol Biol Rev: 2012, 76(2);311-30
[PubMed:22688815] [WorldCat.org] [DOI] (I p)

Tim Clausen, Markus Kaiser, Robert Huber, Michael Ehrmann
HTRA proteases: regulated proteolysis in protein quality control.
Nat Rev Mol Cell Biol: 2011, 12(3);152-62
[PubMed:21326199] [WorldCat.org] [DOI] (I p)


Original publications