Sr1

• Synonyms:

• Description: small regulatory RNA controlling AhrC expression

The gene

Basic information

• Coordinates:

• Gene length:

Database entries

• DBTBS entry:

Additional information

Located between the slp and speA genes.

The RNA

Basic information/ Evolution

• Catalyzed reaction/ biological activity: hybridizes to ahrC mRNA and inhibits AhrC translation. PubMed

Extended information on the RNA

• Kinetic information

• Interactions: Binds ahrC mRNA PubMed

• Localization

Database entries

• Structure:

Additional information

Information on the structure of the RNA can be found in Heidrich et al., 2006

Expression and regulation

• Operon: sr1 PubMed

• Sigma factor: SigA PubMed

• Regulation: Repressed in the presence of glucose by CcpN PubMed

• Regulatory mechanism: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• Antibody:

Labs working on this gene/protein

Sabine Brantl, Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany

References

1. Licht et al. (2005)Implication of CcpN in the regulation of a novel untranslated RNA (SR1) in Bacillus subtilis. Mol. Microbiol. 58: 189-206. PubMed
2. Heidrich et al. (2006) The small untranslated RNA SR1 from the Bacillus subtilis genome is involved in the regulation of arginine catabolism. Mol. Microbiol. 62: 520-536. PubMed
3. Heidrich et al. (2007) In vitro analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA. Nucl. Acids Res. 35: 4331-4346. PubMed