MtnN

• Description: methylthioadenosine nucleosidase
  
  

Gene name	mtnN
Synonyms	yrrU, mtn
Essential	no
Product	methylthioadenosine nucleosidase
Function	methionine salvage
Gene expression levels in SubtiExpress: mtnN
Metabolic function and regulation of this protein in SubtiPathways: Cys, Met & Sulfate assimilation
MW, pI	25 kDa, 4.844
Gene length, protein length	693 bp, 231 aa
Immediate neighbours	mccA, yrrT
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

CymR regulon, Spx regulon

The gene

Basic information

• Locus tag: BSU27270

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: S-adenosyl-L-homocysteine + H₂O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine (according to Swiss-Prot)

• Protein family: MtnN subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1JYS (from Escherichia coli, 51% identity, 70% similarity) PubMed

• UniProt: O32028

• KEGG entry: [3]

• E.C. number: 3.2.2.9

Expression and regulation

• Operon: yrrT-mtnN-mccA-mccB-yrhC PubMed

• Expression browser: mtnN PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed in the presence of cysteine (CymR) PubMed

• Regulatory mechanism:
  • CymR: transcription repression PubMed
  • Spx: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: