MalP

• Description: maltose-specific phosphotransferase system, EIICB of the PTS
  
  

Gene name	malP
Synonyms	glvC
Essential	no
Product	maltose-specific phosphotransferase system, EIICB
Function	maltose uptake and phosphorylation
Gene expression levels in SubtiExpress: malP
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	57 kDa, 8.872
Gene length, protein length	1581 bp, 527 aa
Immediate neighbours	glvR, yfiB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, membrane proteins, phosphoproteins

This gene is a member of the following regulons

CcpA regulon, GlvR regulon

The gene

Basic information

• Locus tag: BSU08200

Phenotypes of a mutant

no growth on maltose as single carbon source PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate (according to Swiss-Prot)

• Protein family: PTS permease, glucose permease (Glc) family PubMed

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P54715

• KEGG entry: [2]

• E.C. number: 2.7.1.69

Expression and regulation

• Operon: malA-glvR-malP PubMed

• Expression browser: malP PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induction by maltose (GlvR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • GlvR: transcription activation PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant: GP110 (spc), available in Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: