LytE

• Description: cell wall hydrolase (major autolysin),endopeptidase-type autolysin
  
  

Gene name	lytE
Synonyms	papQ, cwlF
Essential	no
Product	cell wall hydrolase (major autolysin),endopeptidase-type autolysin
Function	major autolysin, cell separation, cell lysis
MW, pI	37 kDa, 10.713
Gene length, protein length	1029 bp, 343 aa
Immediate neighbours	phoA, citR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell wall degradation/ turnover

This gene is a member of the following regulons

SigH regulon, Spo0A regulon, WalR regulon

The gene

Basic information

• Locus tag: BSU09420

Phenotypes of a mutant

a cwlO lytE mutant is not viable PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: nlpC/p60 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: MreBH-LytE PubMed

• Localization: secreted (according to Swiss-Prot), binds the cell wall PubMed

Database entries

• Structure:

• UniProt: P54421

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: lytE PubMed

• Sigma factor: SigA PubMed, SigH PubMed

• Regulation:
  • repressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • WalR: transcription activation PubMed
  • Spo0A: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: