SipT

• Description: signal peptidase I
  
  

Gene name	sipT
Synonyms
Essential	no
Product	signal peptidase I
Function	protein secretion
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	21 kDa, 9.851
Gene length, protein length	579 bp, 193 aa
Immediate neighbours	fruA, ykoA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

protein secretion, membrane proteins

This gene is a member of the following regulons

DegU regulon

The gene

Basic information

• Locus tag: BSU14410

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)

• Protein family: peptidase S26 family (according to Swiss-Prot)

• Paralogous protein(s): SipS, SipU, SipV

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P71013

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sipT PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • DegU: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands