sipT

sipT
168

signal peptidase I

Locus
BSU_14410
Molecular weight
21.71 kDa
Isoelectric point
9.85
Protein length
193 aaSequenceBlast
Gene length
582 bpSequenceBlast
Function
protein secretion
Product
signal peptidase I
Essential
no
Synonyms
sipT
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0681 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,511,308 → 1,511,889
Phenotypes of a mutant
a ''sipS sipT'' double mutant is not viable PubMed
The protein
Catalyzed reaction/ biological activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to UniProt)
Protein family
peptidase S26 family (according to UniProt)
Structure
4NV4 (PDB) (from B. anthracis, 44% identity)
P71013 (AlphaFold)
Paralogous protein(s)
SipS, SipU, SipV
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
sipT
Description
PubMed
Regulatory mechanism
DegU: activation, PubMed, in degU regulon
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sipT

2025-03-17 17:15:49

ghost

86

fdd1722479b998475c28df0a93c3d509c9451403

3FE2EAED18DFE1E303650E41C77DC01651C14532

Biological materials
Mutant
BKE14410 (ΔsipT::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAAGTGTTTCCTCCTAGAC,  downstream forward: _UP4_TAAAAACGCCTTGCTGGCCT
BKK14410 (ΔsipT::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAAGTGTTTCCTCCTAGAC,  downstream forward: _UP4_TAAAAACGCCTTGCTGGCCT
Labs working on this gene/protein
Jan Maarten van Dijl, Groningen, Netherlands
References
Reviews
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Original Publications
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Page visits: 2837

Time of last update: 2025-04-02 09:19:16

Author of last update: Jstuelk