GrpE

• Description: heat-shock protein (activation of DnaK)
  
  

Gene name	grpE
Synonyms
Essential	no
Product	heat-shock protein
Function	control of DnaK activity
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	21 kDa, 4.264
Gene length, protein length	561 bp, 187 aa
Immediate neighbours	dnaK, hrcA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

chaperones/ protein folding, heat shock proteins

This gene is a member of the following regulons

HrcA regulon

The gene

Basic information

• Locus tag: BSU25480

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: grpE family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: Cytoplasm (Homogeneous) PubMed

Database entries

• Structure:

• UniProt: P15874

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: hrcA-grpE-dnaK-dnaJ-yqeT-yqeU-yqeV PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by heat shock (HrcA) PubMed

• Regulatory mechanism:
  • HrcA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Wolfgang Schumann, Bayreuth University, Germany Homepage