DhbC

• Description: isochorismate synthase
  
  

Gene name	dhbC
Synonyms
Essential	no
Product	isochorismate synthase
Function	biosynthesis of the siderophore bacillibactin
MW, pI	43 kDa, 5.168
Gene length, protein length	1194 bp, 398 aa
Immediate neighbours	dhbE, dhbA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU31990

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

acquisition of iron, iron metabolism, phosphoproteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Chorismate = isochorismate (according to Swiss-Prot)

• Protein family: isochorismate synthase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Ser-271 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3OS6, (from B. anthracis, 56% identity, 70% similarity)

• UniProt: P45744

• KEGG entry: [3]

• E.C. number: 5.4.4.2

Expression and regulation

• Operon: dhbA-dhbC-dhbE-dhbB-dhbF PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: