DapA

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• Description: dihydrodipicolinate synthase <br/><br/>

Gene name	dapA
Synonyms
Essential	yes PubMed
Product	dihydrodipicolinate synthase
Function	biosynthesis of lysine and peptidoglycan
Metabolic function and regulation of this protein in SubtiPathways: <br/>Lys, Thr
MW, pI	30 kDa, 4.928
Gene length, protein length	870 bp, 290 aa
Immediate neighbours	dapG, rnjB
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> <div align="right"> <small>This image was kindly provided by SubtiList</small></div>

<br/><br/><br/><br/><br/><br/>

The gene

Basic information

• Locus tag: BSU16770

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H₂O (according to Swiss-Prot)

• Protein family: DHDPS family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 3CPR (from Corynebacterium glutamicum, 39% identity, 58% similarity) PubMed

• UniProt: Q04796

• KEGG entry: [3]

• E.C. number: 4.2.1.52

Expression and regulation

• Operon:
  • spoVFA-spoVFB-asd-dapG-dapA PubMed
  • asd-dapG-dapA PubMed

• Sigma factor:
  • spoVFA: SigK PubMed
  • asd: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>8345520,,15699190 8098035,, </pubmed>