SigG

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Gene name sigG
Synonyms spoIIIG
Essential no
Product RNA polymerase sporulation forespore-specific
(late) sigma factor SigG
Function transcription of sporulation genes (late forespore)
Gene expression levels in SubtiExpress: sigG
Interactions involving this protein in SubtInteract: SigG
MW, pI 29 kDa, 5.496
Gene length, protein length 780 bp, 260 aa
Immediate neighbours sigE, ylmA
Sequences Protein DNA DNA_with_flanks
Genetic context
SigG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SigG expression.png
















Categories containing this gene/protein

transcription, sigma factors and their control, sporulation proteins

This gene is a member of the following regulons

AbrB regulon, SigF regulon, SigG regulon, SinR regulon, Spo0A regulon

The SigG regulon

The gene

Basic information

  • Locus tag: BSU15330

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: sigma-70 factor family (according to Swiss-Prot)
  • Paralogous protein(s): SigF

Extended information on the protein

  • Kinetic information:
  • Modification:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:
    • the mRNA half-life is about 2.6 min PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Charles Moran, Emory University, NC, USA homepage

Your additional remarks

References

Reviews

Michiel J L de Hoon, Patrick Eichenberger, Dennis Vitkup
Hierarchical evolution of the bacterial sporulation network.
Curr Biol: 2010, 20(17);R735-45
[PubMed:20833318] [WorldCat.org] [DOI] (I p)

The SigG regulon

Original Publications

Christine Diethmaier, Joseph A Newman, Akos T Kovács, Volkhard Kaever, Christina Herzberg, Cecilia Rodrigues, Mirjam Boonstra, Oscar P Kuipers, Richard J Lewis, Jörg Stülke
The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis.
J Bacteriol: 2014, 196(2);265-75
[PubMed:24163345] [WorldCat.org] [DOI] (I p)

Bjorn A Traag, Arturo Ramirez-Peralta, Anna F Wang Erickson, Peter Setlow, Richard Losick
A novel RNA polymerase-binding protein controlling genes involved in spore germination in Bacillus subtilis.
Mol Microbiol: 2013, 89(1);113-22
[PubMed:23678950] [WorldCat.org] [DOI] (I p)

Genevieve Regan, Mitsuhiro Itaya, Patrick J Piggot
Coupling of σG activation to completion of engulfment during sporulation of Bacillus subtilis survives large perturbations to DNA translocation and replication.
J Bacteriol: 2012, 194(22);6264-71
[PubMed:22984259] [WorldCat.org] [DOI] (I p)

Mónica Serrano, Gonçalo Real, Joana Santos, Jorge Carneiro, Charles P Moran, Adriano O Henriques
A negative feedback loop that limits the ectopic activation of a cell type-specific sporulation sigma factor of Bacillus subtilis.
PLoS Genet: 2011, 7(9);e1002220
[PubMed:21935351] [WorldCat.org] [DOI] (I p)

Onuma Chumsakul, Hiroki Takahashi, Taku Oshima, Takahiro Hishimoto, Shigehiko Kanaya, Naotake Ogasawara, Shu Ishikawa
Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation.
Nucleic Acids Res: 2011, 39(2);414-28
[PubMed:20817675] [WorldCat.org] [DOI] (I p)

Lamya Rhayat, Sandra Duperrier, Rut Carballido-López, Olivier Pellegrini, Patrick Stragier
Genetic dissection of an inhibitor of the sporulation sigma factor sigma(G).
J Mol Biol: 2009, 390(5);835-44
[PubMed:19497328] [WorldCat.org] [DOI] (I p)

Amy H Camp, Richard Losick
A feeding tube model for activation of a cell-specific transcription factor during sporulation in Bacillus subtilis.
Genes Dev: 2009, 23(8);1014-24
[PubMed:19390092] [WorldCat.org] [DOI] (I p)

Mónica Serrano, Filipe Vieira, Charles P Moran, Adriano O Henriques
Processing of a membrane protein required for cell-to-cell signaling during endospore formation in Bacillus subtilis.
J Bacteriol: 2008, 190(23);7786-96
[PubMed:18820020] [WorldCat.org] [DOI] (I p)

Amy H Camp, Richard Losick
A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels.
Mol Microbiol: 2008, 69(2);402-17
[PubMed:18485064] [WorldCat.org] [DOI] (I p)

Takao Igarashi, Peter Setlow
Transcription of the Bacillus subtilis gerK operon, which encodes a spore germinant receptor, and comparison with that of operons encoding other germinant receptors.
J Bacteriol: 2006, 188(11);4131-6
[PubMed:16707705] [WorldCat.org] [DOI] (P p)

Louise Evans, Andrea Feucht, Jeff Errington
Genetic analysis of the Bacillus subtilis sigG promoter, which controls the sporulation-specific transcription factor sigma G.
Microbiology (Reading): 2004, 150(Pt 7);2277-2287
[PubMed:15256570] [WorldCat.org] [DOI] (P p)

Mónica Serrano, Alexandre Neves, Cláudio M Soares, Charles P Moran, Adriano O Henriques
Role of the anti-sigma factor SpoIIAB in regulation of sigmaG during Bacillus subtilis sporulation.
J Bacteriol: 2004, 186(12);4000-13
[PubMed:15175314] [WorldCat.org] [DOI] (P p)

Louise Evans, Joanna Clarkson, Michael D Yudkin, Jeff Errington, Andrea Feucht
Analysis of the interaction between the transcription factor sigmaG and the anti-sigma factor SpoIIAB of Bacillus subtilis.
J Bacteriol: 2003, 185(15);4615-9
[PubMed:12867473] [WorldCat.org] [DOI] (P p)

Mónica Serrano, Luísa Côrte, Jason Opdyke, Charles P Moran, Adriano O Henriques
Expression of spoIIIJ in the prespore is sufficient for activation of sigma G and for sporulation in Bacillus subtilis.
J Bacteriol: 2003, 185(13);3905-17
[PubMed:12813085] [WorldCat.org] [DOI] (P p)

A Cabrera-Hernandez, P Setlow
Analysis of the regulation and function of five genes encoding small, acid-soluble spore proteins of Bacillus subtilis.
Gene: 2000, 248(1-2);169-81
[PubMed:10806362] [WorldCat.org] [DOI] (P p)

I Bagyan, B Setlow, P Setlow
New small, acid-soluble proteins unique to spores of Bacillus subtilis: identification of the coding genes and regulation and function of two of these genes.
J Bacteriol: 1998, 180(24);6704-12
[PubMed:9852018] [WorldCat.org] [DOI] (P p)

C Fabret, J A Hoch
A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy.
J Bacteriol: 1998, 180(23);6375-83
[PubMed:9829949] [WorldCat.org] [DOI] (P p)

M Gomez, S M Cutting
Expression of the Bacillus subtilis spoIVB gene is under dual sigma F/sigma G control.
Microbiology (Reading): 1996, 142 ( Pt 12);3453-7
[PubMed:9004507] [WorldCat.org] [DOI] (P p)

E M Kellner, A Decatur, C P Moran
Two-stage regulation of an anti-sigma factor determines developmental fate during bacterial endospore formation.
Mol Microbiol: 1996, 21(5);913-24
[PubMed:8885263] [WorldCat.org] [DOI] (P p)

R Schmidt, A L Decatur, P N Rather, C P Moran, R Losick
Bacillus subtilis lon protease prevents inappropriate transcription of genes under the control of the sporulation transcription factor sigma G.
J Bacteriol: 1994, 176(21);6528-37
[PubMed:7961403] [WorldCat.org] [DOI] (P p)

D Foulger, J Errington
Effects of new mutations in the spoIIAB gene of Bacillus subtilis on the regulation of sigma F and sigma G activities.
J Gen Microbiol: 1993, 139(12);3197-203
[PubMed:8126438] [WorldCat.org] [DOI] (P p)

S R Partridge, J Errington
The importance of morphological events and intercellular interactions in the regulation of prespore-specific gene expression during sporulation in Bacillus subtilis.
Mol Microbiol: 1993, 8(5);945-55
[PubMed:8355618] [WorldCat.org] [DOI] (P p)

J Errington, L Appleby, R A Daniel, H Goodfellow, S R Partridge, M D Yudkin
Structure and function of the spoIIIJ gene of Bacillus subtilis: a vegetatively expressed gene that is essential for sigma G activity at an intermediate stage of sporulation.
J Gen Microbiol: 1992, 138(12);2609-18
[PubMed:1487728] [WorldCat.org] [DOI] (P p)

N Illing, J Errington
Genetic regulation of morphogenesis in Bacillus subtilis: roles of sigma E and sigma F in prespore engulfment.
J Bacteriol: 1991, 173(10);3159-69
[PubMed:1902463] [WorldCat.org] [DOI] (P p)

D X Sun, R M Cabrera-Martinez, P Setlow
Control of transcription of the Bacillus subtilis spoIIIG gene, which codes for the forespore-specific transcription factor sigma G.
J Bacteriol: 1991, 173(9);2977-84
[PubMed:1902213] [WorldCat.org] [DOI] (P p)

P Fajardo-Cavazos, F Tovar-Rojo, P Setlow
Effect of promoter mutations and upstream deletions on the expression of genes coding for small, acid-soluble spore proteins of Bacillus subtilis.
J Bacteriol: 1991, 173(6);2011-6
[PubMed:1900507] [WorldCat.org] [DOI] (P p)

Y Nakatani, W L Nicholson, K D Neitzke, P Setlow, E Freese
Sigma-G RNA polymerase controls forespore-specific expression of the glucose dehydrogenase operon in Bacillus subtilis.
Nucleic Acids Res: 1989, 17(3);999-1017
[PubMed:2493633] [WorldCat.org] [DOI] (P p)

D X Sun, P Stragier, P Setlow
Identification of a new sigma-factor involved in compartmentalized gene expression during sporulation of Bacillus subtilis.
Genes Dev: 1989, 3(2);141-9
[PubMed:2497051] [WorldCat.org] [DOI] (P p)

R M Jonas, E A Weaver, T J Kenney, C P Moran, W G Haldenwang
The Bacillus subtilis spoIIG operon encodes both sigma E and a gene necessary for sigma E activation.
J Bacteriol: 1988, 170(2);507-11
[PubMed:2448286] [WorldCat.org] [DOI] (P p)

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