SpoIIIJ

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  • Description: Sec-independent membrane protein translocase, essential for SigG activity at stage III, involved in the assembly of the SpoIIIA-SpoIIQ complex

Gene name spoIIIJ
Synonyms spo0J87
Essential no
Product membrane protein translocase
Function membrane insertion of proteins and protein secretion
Gene expression levels in SubtiExpress: spoIIIJ
Interactions involving this protein in SubtInteract: SpoIIIJ
MW, pI 29 kDa, 9.992
Gene length, protein length 783 bp, 261 aa
Immediate neighbours jag, rnpA
Sequences Protein DNA DNA_with_flanks
Genetic context
ThdF jag spoIIIJ rnpA rpmH context.png
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SpoIIIJ expression.png















Categories containing this gene/protein

protein secretion, sporulation/ other, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU41040

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: membrane protein translocase, facilitates insertion of SpoIIIAE into the membrane PubMed
  • Protein family: YidC/Oxa1/Alb3 family PubMed
  • Paralogous protein(s): YidC2, one of the two proteins has to be present for viability PubMed

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (complex medium with amino acids, without glucose): 1044 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Richard Losick, Harvard University, Cambridge, USA homepage

Adriano Henriques, Lisbon, Portugal homepage

Your additional remarks

References

Reviews

Ross E Dalbey, Peng Wang, Jan Maarten van Dijl
Membrane proteases in the bacterial protein secretion and quality control pathway.
Microbiol Mol Biol Rev: 2012, 76(2);311-30
[PubMed:22688815] [WorldCat.org] [DOI] (I p)

Soledad Funes, Frank Kauff, Eli O van der Sluis, Martin Ott, Johannes M Herrmann
Evolution of YidC/Oxa1/Alb3 insertases: three independent gene duplications followed by functional specialization in bacteria, mitochondria and chloroplasts.
Biol Chem: 2011, 392(1-2);13-9
[PubMed:21194367] [WorldCat.org] [DOI] (I p)

Peng Wang, Ross E Dalbey
Inserting membrane proteins: the YidC/Oxa1/Alb3 machinery in bacteria, mitochondria, and chloroplasts.
Biochim Biophys Acta: 2011, 1808(3);866-75
[PubMed:20800571] [WorldCat.org] [DOI] (P p)

Martin van der Laan, Nico P Nouwen, Arnold J M Driessen
YidC--an evolutionary conserved device for the assembly of energy-transducing membrane protein complexes.
Curr Opin Microbiol: 2005, 8(2);182-7
[PubMed:15802250] [WorldCat.org] [DOI] (P p)


Original publications

Luísa Côrte, Filipa Valente, Mónica Serrano, Cláudio M Gomes, Charles P Moran, Adriano O Henriques
A conserved cysteine residue of Bacillus subtilis SpoIIIJ is important for endospore development.
PLoS One: 2014, 9(8);e99811
[PubMed:25133632] [WorldCat.org] [DOI] (I e)

Yanping Geng, Jeanine de Keyzer, Dirk-Jan Scheffers, Arnold J M Driessen
Defining the region of Bacillus subtilis SpoIIIJ that is essential for its sporulation-specific function.
J Bacteriol: 2014, 196(7);1318-24
[PubMed:24443530] [WorldCat.org] [DOI] (I p)

Chun-Kai Yang, Chung-Dar Lu, Phang C Tai
Differential expression of secretion machinery during bacterial growth: SecY and SecF decrease while SecA increases during transition from exponential phase to stationary phase.
Curr Microbiol: 2013, 67(6);682-7
[PubMed:23852076] [WorldCat.org] [DOI] (I p)

Shinobu Chiba, Koreaki Ito
Multisite ribosomal stalling: a unique mode of regulatory nascent chain action revealed for MifM.
Mol Cell: 2012, 47(6);863-72
[PubMed:22864117] [WorldCat.org] [DOI] (I p)

Shinobu Chiba, Anne Lamsa, Kit Pogliano
A ribosome-nascent chain sensor of membrane protein biogenesis in Bacillus subtilis.
EMBO J: 2009, 28(22);3461-75
[PubMed:19779460] [WorldCat.org] [DOI] (I p)

Manfred J Saller, Fabrizia Fusetti, Arnold J M Driessen
Bacillus subtilis SpoIIIJ and YqjG function in membrane protein biogenesis.
J Bacteriol: 2009, 191(21);6749-57
[PubMed:19717609] [WorldCat.org] [DOI] (I p)

Mónica Serrano, Filipe Vieira, Charles P Moran, Adriano O Henriques
Processing of a membrane protein required for cell-to-cell signaling during endospore formation in Bacillus subtilis.
J Bacteriol: 2008, 190(23);7786-96
[PubMed:18820020] [WorldCat.org] [DOI] (I p)

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)

Amy H Camp, Richard Losick
A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels.
Mol Microbiol: 2008, 69(2);402-17
[PubMed:18485064] [WorldCat.org] [DOI] (I p)

Helena B Thomaides, Ella J Davison, Lisa Burston, Hazel Johnson, David R Brown, Alison C Hunt, Jeffery Errington, Lloyd Czaplewski
Essential bacterial functions encoded by gene pairs.
J Bacteriol: 2007, 189(2);591-602
[PubMed:17114254] [WorldCat.org] [DOI] (P p)

Aileen Rubio, Xin Jiang, Kit Pogliano
Localization of translocation complex components in Bacillus subtilis: enrichment of the signal recognition particle receptor at early sporulation septa.
J Bacteriol: 2005, 187(14);5000-2
[PubMed:15995216] [WorldCat.org] [DOI] (P p)

Mónica Serrano, Luísa Côrte, Jason Opdyke, Charles P Moran, Adriano O Henriques
Expression of spoIIIJ in the prespore is sufficient for activation of sigma G and for sporulation in Bacillus subtilis.
J Bacteriol: 2003, 185(13);3905-17
[PubMed:12813085] [WorldCat.org] [DOI] (P p)

Harold Tjalsma, Sierd Bron, Jan Maarten van Dijl
Complementary impact of paralogous Oxa1-like proteins of Bacillus subtilis on post-translocational stages in protein secretion.
J Biol Chem: 2003, 278(18);15622-32
[PubMed:12586834] [WorldCat.org] [DOI] (P p)

Takako Murakami, Koki Haga, Michio Takeuchi, Tsutomu Sato
Analysis of the Bacillus subtilis spoIIIJ gene and its Paralogue gene, yqjG.
J Bacteriol: 2002, 184(7);1998-2004
[PubMed:11889108] [WorldCat.org] [DOI] (P p)

J Errington, L Appleby, R A Daniel, H Goodfellow, S R Partridge, M D Yudkin
Structure and function of the spoIIIJ gene of Bacillus subtilis: a vegetatively expressed gene that is essential for sigma G activity at an intermediate stage of sporulation.
J Gen Microbiol: 1992, 138(12);2609-18
[PubMed:1487728] [WorldCat.org] [DOI] (P p)

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