FloT

• Description: similar to flottilin 1, orchestration of physiological processes in lipid microdomains
  
  

Gene name	floT
Synonyms	yuaG, yuaH
Essential	no
Product	unknown
Function	early stages of sporulation
MW, pI	55 kDa, 5.135
Gene length, protein length	1527 bp, 509 aa
Immediate neighbours	yuaI, yuaF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biofilm formation, membrane dynamics, membrane proteins sporulation/ other, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigW regulon

The gene

Basic information

• Locus tag: BSU31010

Phenotypes of a mutant

• • delayed onset of sporulation, reduced sporulation frequency
  • a floT yqfA double mutant does not induce KinC-dependent biofilm formation upon addition of surfactin PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • membrane associated PubMed
  • co-localizes with YqfA and KinC in discrete foci membrane PubMed

Database entries

• Structure:

• UniProt: O32076

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yuaF-floT-yuaI PubMed

• Sigma factor: SigW PubMed

• Regulation:
  • expressed upon cell wall stress (SigW) PubMed
  • repressed by casamino acids PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: