SigW regulon

Regulator	SigW
Overview on the regulons (wiki page) Overview on the regulons (Excel file)

• The SigW regulon is induced by alkaline shock and by polymyxin B, vancomycin, cephalosporin C, D-cycloserine, and triton X-100.
• The SigW regulon is downregulated in a rocG gudB mutant PubMed
• The SigW regulon mediates resistance to cell wall antibiotics

Related SubtiWiki pages

• Resistance against toxins/ antibiotics

Genes in this regulon

• bcrC
• divIC
• fabF
• fatR
• fosB
• pbpE-racX
• pspA
• sasA
• sigW-rsiW
• spo0M
• sppA
• spx
• xpaC-yaaN-yaaO
• ybfO
• ybfP
• ybfQ
• yceC-yceD-yceE-yceF-yceG-yceH
• ydbS-ydbT
• ydjO
• ydjP
• yeaA
• yfhL-yfhM
• yjbC
• yjoB
• yknW-yknX-yknY-yknZ
• yoaF
• yoaG
• yobJ
• yozO
• yqeZ-floA-yqfB
• yqjL
• yrhH
• yrhJ
• ysdB
• yteJ
• ythP
• ythQ
• yuaF-floT-yuaI
• yvlA-yvlB-yvlC-yvlD
• ywbN
• ywbO
• ywnJ
• ywrE
• yxjI
• yxzE

Important publications on the SigW regulon

John D Helmann
Bacillus subtilis extracytoplasmic function (ECF) sigma factors and defense of the cell envelope.
Curr Opin Microbiol: 2016, 30;122-132
[PubMed:26901131] [WorldCat.org] [DOI] (I p)

Chun-Kai Yang, Phang C Tai, Chung-Dar Lu
Time-related transcriptome analysis of B. subtilis 168 during growth with glucose.
Curr Microbiol: 2014, 68(1);12-20
[PubMed:23934352] [WorldCat.org] [DOI] (I p)

Jessica C Zweers, Pierre Nicolas, Thomas Wiegert, Jan Maarten van Dijl, Emma L Denham
Definition of the σ(W) regulon of Bacillus subtilis in the absence of stress.
PLoS One: 2012, 7(11);e48471
[PubMed:23155385] [WorldCat.org] [DOI] (I p)

Yong Heon Lee, Anthony W Kingston, John D Helmann
Glutamate dehydrogenase affects resistance to cell wall antibiotics in Bacillus subtilis.
J Bacteriol: 2012, 194(5);993-1001
[PubMed:22178969] [WorldCat.org] [DOI] (I p)

Thorsten Mascher, Anna-Barbara Hachmann, John D Helmann
Regulatory overlap and functional redundancy among Bacillus subtilis extracytoplasmic function sigma factors.
J Bacteriol: 2007, 189(19);6919-27
[PubMed:17675383] [WorldCat.org] [DOI] (P p)

Bronwyn G Butcher, John D Helmann
Identification of Bacillus subtilis sigma-dependent genes that provide intrinsic resistance to antimicrobial compounds produced by Bacilli.
Mol Microbiol: 2006, 60(3);765-82
[PubMed:16629676] [WorldCat.org] [DOI] (P p)

Min Cao, Phil A Kobel, Maud M Morshedi, Ming Fang Winston Wu, Chris Paddon, John D Helmann
Defining the Bacillus subtilis sigma(W) regulon: a comparative analysis of promoter consensus search, run-off transcription/macroarray analysis (ROMA), and transcriptional profiling approaches.
J Mol Biol: 2002, 316(3);443-57
[PubMed:11866510] [WorldCat.org] [DOI] (P p)

M S Turner, J D Helmann
Mutations in multidrug efflux homologs, sugar isomerases, and antimicrobial biosynthesis genes differentially elevate activity of the sigma(X) and sigma(W) factors in Bacillus subtilis.
J Bacteriol: 2000, 182(18);5202-10
[PubMed:10960106] [WorldCat.org] [DOI] (P p)

X Huang, A Gaballa, M Cao, J D Helmann
Identification of target promoters for the Bacillus subtilis extracytoplasmic function sigma factor, sigma W.
Mol Microbiol: 1999, 31(1);361-71
[PubMed:9987136] [WorldCat.org] [DOI] (P p)

X Huang, K L Fredrick, J D Helmann
Promoter recognition by Bacillus subtilis sigmaW: autoregulation and partial overlap with the sigmaX regulon.
J Bacteriol: 1998, 180(15);3765-70
[PubMed:9683469] [WorldCat.org] [DOI] (P p)