DisA
- Description: DNA integrity scanning protein, delays sporulation in the case of chromosome damage, has diadenylate cyclase activity
Gene name | disA |
Synonyms | yacK |
Essential | no |
Product | DNA integrity scanning protein, has diadenylate cyclase activity |
Function | control of sporulation initiation |
Metabolic function and regulation of this protein in SubtiPathways: Stress | |
MW, pI | 40 kDa, 5.569 |
Gene length, protein length | 1080 bp, 360 aa |
Immediate neighbours | radA, yacL |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
Categories containing this gene/protein
cell division, metabolism of signalling nucleotides, sporulation/ other, general stress proteins (controlled by SigB), cell envelope stress proteins (controlled by SigM, W, X, Y), heat shock proteins
This gene is a member of the following regulons
CtsR regulon, SigB regulon, SigM regulon
The gene
Basic information
- Locus tag: BSU00880
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: synthesizes the small molecule cyclic diadenosine monophosphate (c-di-AMP) PubMed
- Protein family: disA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 3C23
- UniProt: P37573
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant: YA5 disA::tet, available in Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References