ParC

• Description: subunit of DNA topoisomerase IV
  
  

Gene name	parC
Synonyms	grlA
Essential	yes PubMed
Product	subunit of DNA topoisomerase IV
Function	chromosome segregation and compaction
MW, pI	91 kDa, 6.307
Gene length, protein length	2418 bp, 806 aa
Immediate neighbours	parE, ynfC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU18100

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

DNA condensation/ segregation, essential genes

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: topoisomerase gyrA/parC subunit family (according to Swiss-Prot)

• Paralogous protein(s): GyrA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot), Cytoplasm (Homogeneous) PubMed polar localization in actively growing cells PubMed

Database entries

• Structure: 1WP5 (C-terminal domain, Geobacillus stearothermophilus)

• UniProt: Q45066

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: parE-parC PubMed

• Sigma factor:

• Regulation:
  • induced by DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: