McsA

• Description: modulator of CtsR-dependent repression, McsA activates kinase activity of McsB
  
  

Gene name	mcsA
Synonyms	yacH
Essential	no
Product	activator of McsB kinase activity
Function	control of CtsR activity
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	20 kDa, 6.624
Gene length, protein length	555 bp, 185 aa
Immediate neighbours	ctsR, mcsB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU00840

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

transcription factors and their control, sporulation proteins, general stress proteins (controlled by SigB), heat shock proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: McsA-McsB-CtsR, McsA-McsB

• Localization:

Database entries

• Structure:

• UniProt: P37569

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ctsR-mcsA-mcsB-clpC-radA-disA PubMed

• Sigma factor: SigA PubMed, SigB PubMed1 PubMed2, SigF PubMed

• Regulation:
  • expressed early during sporulation in the forespore (SigF) PubMed
  • induced by stress (SigB) PubMed
  • induced by heat (CtsR) PubMed

• Regulatory mechanism:
  • CtsR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: