Sandbox

• Description: two-component response regulator, control of cellular responses to protein secretion stress
  
  

Gene name	cssR
Synonyms	yvqA
Essential	no
Product	two-component response regulator
Function	control of cellular responses to protein secretion stress
MW, pI	26 kDa, 5.071
Gene length, protein length	675 bp, 225 aa
Immediate neighbours	htrB, cssS
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU33010

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: OmpR family of two-component response regulators

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• Swiss prot entry: O32192

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Y W Chow, R Pietranico, A Mukerji
Studies of oxygen binding energy to hemoglobin molecule.
Biochem Biophys Res Commun: 1975, 66(4);1424-31
[PubMed:6] [WorldCat.org] [DOI] (P p)

W A Hendrickson, K B Ward
Atomic models for the polypeptide backbones of myohemerythrin and hemerythrin.
Biochem Biophys Res Commun: 1975, 66(4);1349-56
[PubMed:5] [WorldCat.org] [DOI] (I p)

R J Smith, R G Bryant
Metal substitutions incarbonic anhydrase: a halide ion probe study.
Biochem Biophys Res Commun: 1975, 66(4);1281-6
[PubMed:3] [WorldCat.org] [DOI] (P p)

K S Bose, R H Sarma
Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution.
Biochem Biophys Res Commun: 1975, 66(4);1173-9
[PubMed:2] [WorldCat.org] [DOI] (I p)

J Marniemi, M G Parkki
Radiochemical assay of glutathione S-epoxide transferase and its enhancement by phenobarbital in rat liver in vivo.
Biochem Pharmacol: 1975, 24(17);1569-72
[PubMed:9] [WorldCat.org] [DOI] (P p)

A B Makar, K E McMartin, M Palese, T R Tephly
Formate assay in body fluids: application in methanol poisoning.
Biochem Med: 1975, 13(2);117-26
[PubMed:1] [WorldCat.org] [DOI] (P p)

1. Darmon E, Noone D, Masson A, Bron S, Kuipers OP, Devine KM, van Dijl JM. (2002) A novel class of heat and secretion stress-responsive genes is controlled by the autoregulated CssRS two-component system of Bacillus subtilis. J Bacteriol. 184(20): 5661-71. PubMed
2. Hyyryläinen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Prágai Z, Bron S, van Dijl JM, Kontinen VP. (2001) A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress. Mol Microbiol. 41(5): 1159-72. PubMed