PurE

• Description: phosphoribosylaminoimidazole carboxylase (ATP-dependent)
  
  

Gene name	purE
Synonyms
Essential	no
Product	phosphoribosylaminoimidazole carboxylase (ATP-dependent)
Function	purine biosynthesis
MW, pI	17 kDa, 5.199
Gene length, protein length	486 bp, 162 aa
Immediate neighbours	yebG, purK
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO₂ (according to Swiss-Prot)

• Protein family: AIR carboxylase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• Swiss prot entry: P12044

• KEGG entry: BSU06420

• E.C. number: 4.1.1.21

Expression and regulation

• Operon: purE-purK-purB-purC-purS-purQ-purL-purF-purM-purN-purH-purD

• Sigma factor: SigA

• Regulation: induced in the absence of purine nucleotides (PurR)

• Regulatory mechanism: PurR: transcription repression (molecular inducer: PRPP)

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed