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  • Description: replication initiation protein

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context.gif]].*
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Gene name dnaA context.gif]].*
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Synonyms dnaH, dnaJ, dnaK context.gif]].*
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Essential yes PubMed context.gif]].*
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Product replication initiation protein context.gif]].*
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Function DNA replication context.gif]].*
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MW, pI 50 kDa, 6.035 context.gif]].*
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Gene length, protein length 1338 bp, 446 aa context.gif]].*
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Immediate neighbours rpmH, dnaN context.gif]].*
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[1]].*
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[2]].*
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context.gif]].*
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Genetic context
DnaA context.gif.*
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The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [3]
  • SubtiList entry: [4]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
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|-YabAcontext.gif]].*
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|-DnaN PubMed, DnaAcontext.gif]].*
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|-DnaD PubMed
  • Localization: throughout the cytoplasm PubMed

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry: [5]].*
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|-bin/www_bget?bsu+BSU00010]
  • E.C. number:

Additional information

Expression and regulation

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|-dnaN  PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • twocontext.gif]].*
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|-hybrid system:
  • Antibody:

Labs working on this gene/protein

Philippe Noirot, Jouycontext.gif]].*

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|-encontext.gif]].*
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|-Josas, France homepage

Your additional remarks

References

  1. Imai et al. (2000) Subcellular localization of Dnacontext.gif]].*
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|-initiation proteins of Bacillus subtilis: evidence that chromosome replication begins at either edge of the nucleoids. Mol. Microbiol. 36: 1037context.gif]].*
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|-1048. PubMed
  1. Ishigocontext.gif]].*
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|-Oka et al. (2001) DnaD protein of Bacillus subtilis interacts with DnaA, the initiator protein of replication. J. Bacteriol. 183: 2148context.gif]].*
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|-2150. PubMed
  1. Noirotcontext.gif]].*
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|-Gros et al. (2002) An expanded view of bacterial DNA replication. Proc. Natl. Acad. Sci. USA 99: 8342context.gif]].*
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|-8347. PubMed
  1. Noirotcontext.gif]].*
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|-Gros et al. (2002) Functional dissection of YabA, a negative regulator of DNA replication initiation in Bacillus Title Proc. Natl. Acad. Sci. USA 103: 2368context.gif]].*
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|-2373. PubMed
  1. Ogasawara et al. (1985) Structure and function of the region of the replication origin of the Bacillus subtilis chromosome. IV. Transcription of the oriC region and expression of DNA gyrase genes and other open reading frames.Nucl. Acids Res. 11: 2267context.gif]].*
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|-2279. PubMed
  1. Fukuoka et al. (1990) Purification and characterization of an initiation protein for chromosomal replication, DnaA, in Bacillus subtilis. J. Biochem. 107: 732context.gif]].*
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|-739. PubMed
  1. Molle et al. (2003) The Spo0A regulon of Bacillus subtilis.Mol. Microbiol. 50: 1683context.gif]].*
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|-1701. PubMed
  1. Author1, Author2 & Author3 (year) Title Journal volume: pagecontext.gif]].*
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|-page. PubMed