LtaS

• Description: polyglycerolphosphate lipoteichoic acid synthase
  
  

Gene name	ltaS
Synonyms	yflE
Essential	no
Product	major lipoteichoic acid synthase
Function	biosynthesis of lipoteichoic acid
Gene expression levels in SubtiExpress: ltaS
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	74 kDa, 5.202
Gene length, protein length	1947 bp, 649 aa
Immediate neighbours	nagP, yflD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, membrane proteins, phosphoproteins

The gene

Basic information

• Locus tag:

Phenotypes of a mutant

• induction of SigM and SigX activities PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: LTA synthase family (according to Swiss-Prot)

• Paralogous protein(s): YfnI, YqgS, YvgJ

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on Thr-297 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane, at the septum of the cell PubMed
  • extracellular (signal peptide) PubMed

Database entries

• Structure: 2W8D

• UniProt: O34952

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ltaS (according to DBTBS)

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • GP1389 ltaS::aphA3, available in Jörg Stülke's lab
  • GP1396 ltaS::tet, available in Jörg Stülke's lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Nathalie T Reichmann, Angelika Gründling
Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes.
FEMS Microbiol Lett: 2011, 319(2);97-105
[PubMed:21388439] [WorldCat.org] [DOI] (I p)

Iain C Sutcliffe
Priming and elongation: dissection of the lipoteichoic acid biosynthetic pathway in Gram-positive bacteria.
Mol Microbiol: 2011, 79(3);553-6
[PubMed:21255102] [WorldCat.org] [DOI] (I p)