ManR

• Description: transcriptional activator of the manP-manA-yjdF operon
  
  

Gene name	manR
Synonyms	yjdC
Essential	no
Product	transcriptional activator, PRD-type
Function	regulation of mannose utilization
Gene expression levels in SubtiExpress: manR
Interactions involving this protein in SubtInteract: ManR
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	75 kDa, 8.04
Gene length, protein length	1944 bp, 648 aa
Immediate neighbours	yjdB, manP
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

CcpA regulon, ManR regulon

The ManR regulon:

• manP-manA-yjdF, manR

The gene

Basic information

• Locus tag: BSU12000

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation by ManP inactivates ManR (in the absence of mannose), phosphorylation by HPr stimluates ManR PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • ManP-ManR PubMed
  • HPr-ManR PubMed

• Localization:

Database entries

• Structure:

• UniProt: O31644

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: manR PubMed

• Expression browser: manR PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by mannose (ManR) PubMed
  • repressed by glucose (CcpA, ManR) PubMed

• Regulatory mechanism:
  • ManR: transcription activation in the presence of mannose and absence of glucose PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: