YrvO

• Description: cysteine desulfurase involved in tRNA thiolation
  
  

Gene name	yrvO
Synonyms	nifS, iscS
Essential	yes PubMed
Product	cysteine desulfurase
Function	tRNA modification
MW, pI	41 kDa, 5.463
Gene length, protein length	1137 bp, 379 aa
Immediate neighbours	trmU, cymR
Gene sequence (+200bp)	Protein sequence
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

essential genes, translation, phosphoproteins

This gene is a member of the following regulons

stringent response

The gene

Basic information

• Locus tag: BSU27510

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): NifS, NifZ, SufS, YcbU

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-385 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1EG5 (from Thermotoga maritima, 37% identity, 54% similarity) PubMed

• UniProt: O34599

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: cymR-yrvO-trmU PubMed

• Expression browser: yrvO PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • RelA dependent downregulation (Class I) during stringent response PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: