RNA polymerase

Parent categories	3. Information processing 3.2. RNA synthesis and degradation 3.2.1. Transcription
Neighbouring categories	Sigma factors
Related categories	protein-protein interactions
Overview on the categories (Excel file) All genes and their categories (Excel file)

Components of the RNA polymerase

Core subunits

• RpoA: alpha subunit
• RpoB: beta subunit
• RpoC: beta' subunit

• The stoichiometry of the enzyme is RpoA(2)-RpoB-RpoC

Sigma factors

• In addition to the housekeeping sigma factor, SigA, there are several other sigma factors with different promoter recognition specifiity that are active under specific conditions (such as stress or sporulation)

Small accessory subunits

• RpoE: delta subunit
• YloH: omega subunit

Other temporary components

• NusA: essential elongation factor

References

The structure of RNA polymerase

Elecia B Johnston, Peter J Lewis, Renate Griffith
The interaction of Bacillus subtilis sigmaA with RNA polymerase.
Protein Sci: 2009, 18(11);2287-97
[PubMed:19735077] [WorldCat.org] [DOI] (I p)

Sergei Borukhov, Evgeny Nudler
RNA polymerase holoenzyme: structure, function and biological implications.
Curr Opin Microbiol: 2003, 6(2);93-100
[PubMed:12732296] [WorldCat.org] [DOI] (P p)

Katsuhiko S Murakami, Seth A Darst
Bacterial RNA polymerases: the wholo story.
Curr Opin Struct Biol: 2003, 13(1);31-9
[PubMed:12581657] [WorldCat.org] [DOI] (P p)

S A Darst
Bacterial RNA polymerase.
Curr Opin Struct Biol: 2001, 11(2);155-62
[PubMed:11297923] [WorldCat.org] [DOI] (P p)

Important original publications: PubMed

Houra Merrikh, Cristina Machón, William H Grainger, Alan D Grossman, Panos Soultanas
Co-directional replication-transcription conflicts lead to replication restart.
Nature: 2011, 470(7335);554-7
[PubMed:21350489] [WorldCat.org] [DOI] (I p)