RNA switch

RNA switches are regulatory systems that rely on alternative mRNA structures.

RNA switches may be triggered by proteins, tRNAs (T-box), or metabolites (riboswitches)

List of Bacillus subtilis RNAswitches

• Protein-dependent RNA switches

• T-box

• Riboswitches
  • A-box
  • FMN-box
  • G-box
  • Gly-box
  • L-box
  • M-box
  • preQ1 riboswitch
  • ribozyme: glmS
  • S-box
  • Thi-box

• Potential additional RNA switches

The function of these potential RNA structures is unknown. They were suggested to control the mentioned genes.

• • ydaO-yuaA switch: ydaO, ktrA
  • ykkC-yxkD switch: ykkC, yxkD
  • yybP-ykoY switch: yybP, ykoY
  • ylbH switch: ylbH
  • L10 leader: rplJ
  • L13 leader: rplM
  • L19 leader: rplS
  • L20 leader: in front of the infC-rpmI-rplT operon
  • L21_leader:in front of the rplU-ysxB-rpmA operon

Important Reviews

Michael D Dambach, Wade C Winkler
Expanding roles for metabolite-sensing regulatory RNAs.
Curr Opin Microbiol: 2009, 12(2);161-9
[PubMed:19250859] [WorldCat.org] [DOI] (I p)

Frank J Grundy, Tina M Henkin
Regulation of gene expression by effectors that bind to RNA.
Curr Opin Microbiol: 2004, 7(2);126-31
[PubMed:15063848] [WorldCat.org] [DOI] (P p)