Difference between revisions of "LiaR"
| Line 94: | Line 94: | ||
* '''Regulation:''' ''[[liaI]]'': induced by bacitracin ([[LiaR]]) | * '''Regulation:''' ''[[liaI]]'': induced by bacitracin ([[LiaR]]) | ||
| + | ** repressed during logrithmic growth ([[AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed] | ||
''[[liaS]]'': constitutive | ''[[liaS]]'': constitutive | ||
* '''Regulatory mechanism:''' [[LiaR]]: transcription activation | * '''Regulatory mechanism:''' [[LiaR]]: transcription activation | ||
| + | ** [[AbrB]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed] | ||
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 16:14, 11 June 2009
- Description: two-component response regulator, regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin
| Gene name | liaR |
| Synonyms | yvqC |
| Essential | no |
| Product | two-component response regulator |
| Function | regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin |
| MW, pI | 22 kDa, 4.956 |
| Gene length, protein length | 633 bp, 211 aa |
| Immediate neighbours | gerAC, liaS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU33080
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- Swiss prot entry: O32197
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor: SigA
liaS: constitutive
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Thorsten Mascher, Karlsruhe Institute of Technology, Germany link
Your additional remarks
References
- Jordan, S., A. Junker, J. D. Helmann, and T. Mascher. 2006. Regulation of LiaRS-dependent gene expression in Bacillus subtilis: identification of inhibitor proteins, regulator binding sites, and target genes of a conserved cell envelope stress-sensing two-component system. J. Bacteriol. 188: 5153-5166. PubMed
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
