Difference between revisions of "CapA"

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(Reviews)
(Expression and regulation)
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* '''Additional information:'''  
 
* '''Additional information:'''  
 
** The operon is not expressed in the lab strain 168 due to lack of expression of [[DegQ]] resulting in inactivity of [[DegS]] and [[DegU]] {{PubMed|21965392}}
 
** The operon is not expressed in the lab strain 168 due to lack of expression of [[DegQ]] resulting in inactivity of [[DegS]] and [[DegU]] {{PubMed|21965392}}
** expression of the operon is reduced in ''[[motA]]'' or ''[[motB]]'' mutants due to reduced [[DegU]] phosphorylation {{PubMed|24296669}}
+
** expression of the operon is increased in ''[[motA]]'' or ''[[motB]]'' mutants due to increased [[DegU]] phosphorylation {{PubMed|24296669}}
  
 
=Biological materials =
 
=Biological materials =

Revision as of 13:04, 15 January 2015

  • Description: similar to capsular polyglutamate biosynthesis

Gene name capA
Synonyms ywtB, pgsA
Essential no
Product unknown
Function unknown
Gene expression levels in SubtiExpress: capA
MW, pI 42 kDa, 9.274
Gene length, protein length 1140 bp, 380 aa
Immediate neighbours capE, capC
Gene sequence (+200bp) Protein sequence
Genetic context
YwtB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
500px















Categories containing this gene/protein

capsule biosynthesis and degradation

This gene is a member of the following regulons

DegU regulon

The gene

Basic information

  • Locus tag: BSU35880

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:
    • The operon is not expressed in the lab strain 168 due to lack of expression of DegQ resulting in inactivity of DegS and DegU PubMed
    • expression of the operon is increased in motA or motB mutants due to increased DegU phosphorylation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Massimiliano Marvasi, Pieter T Visscher, Lilliam Casillas Martinez
Exopolymeric substances (EPS) from Bacillus subtilis: polymers and genes encoding their synthesis.
FEMS Microbiol Lett: 2010, 313(1);1-9
[PubMed:20735481] [WorldCat.org] [DOI] (I p)

Thomas Candela, Agnès Fouet
Poly-gamma-glutamate in bacteria.
Mol Microbiol: 2006, 60(5);1091-8
[PubMed:16689787] [WorldCat.org] [DOI] (P p)


Original publications

Additional publications: PubMed