Difference between revisions of "EzrA"
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| + | ** inhibits [[FtsZ]] polymerization {{PubMed|25403286}} | ||
| + | ** recruits [[PBP1|ponA]] to the division septum {{PubMed|25403286}} | ||
* '''Protein family:''' ezrA family (according to Swiss-Prot) | * '''Protein family:''' ezrA family (according to Swiss-Prot) | ||
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
** [[EzrA]]-[[UgtP]] {{PubMed|17662947}} | ** [[EzrA]]-[[UgtP]] {{PubMed|17662947}} | ||
| − | ** [[FtsZ]]-[[EzrA]] {{PubMed|10449747}} | + | ** [[FtsZ]]-[[EzrA]] {{PubMed|25403286,10449747}} |
** [[EzrA]]-[[GpsB]] {{PubMed|18363795}} | ** [[EzrA]]-[[GpsB]] {{PubMed|18363795}} | ||
** [[EzrA]]-[[PonA]] {{PubMed|18363795}} | ** [[EzrA]]-[[PonA]] {{PubMed|18363795}} | ||
| − | * '''[[Localization]]:''' membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed] | + | * '''[[Localization]]:''' |
| − | ** 1 transmembrane domain at the N-terminus | + | ** membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed] |
| + | ** 1 transmembrane domain at the N-terminus {{PubMed|25403286}} | ||
=== Database entries === | === Database entries === | ||
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU29610&redirect=T BSU29610] | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU29610&redirect=T BSU29610] | ||
| − | * '''Structure:''' | + | * '''Structure:''' [http://www.pdb.org/pdb/explore/explore.do?structureId=4uxv 4UXV] (the 60 kDa cytoplasmic domain) {{PubMed|25403286}} |
* '''UniProt:''' [http://www.uniprot.org/uniprot/O34894 O34894] | * '''UniProt:''' [http://www.uniprot.org/uniprot/O34894 O34894] | ||
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<pubmed> 19680248 19884039 </pubmed> | <pubmed> 19680248 19884039 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed>10449747,16420366,15317782,16549676,17662947,12368265,18363795,9387221 15317798 , 19429628, 18763711 21401734 24222488 23701187 17718511 24218584 24097947 24825009 25068683 </pubmed> | + | <pubmed>10449747,16420366,15317782,16549676,17662947,12368265,18363795,9387221 15317798 , 19429628, 18763711 21401734 24222488 23701187 17718511 24218584 24097947 24825009 25068683 25403286 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 09:19, 19 November 2014
- Description: negative regulator of FtsZ ring formation
| Gene name | ezrA |
| Synonyms | ytwP |
| Essential | no |
| Product | FtsZ-interacting protein |
| Function | control of FtsZ ring formation |
| Gene expression levels in SubtiExpress: ezrA | |
| Interactions involving this protein in SubtInteract: EzrA | |
| MW, pI | 64 kDa, 4.757 |
| Gene length, protein length | 1686 bp, 562 aa |
| Immediate neighbours | braB, hisJ |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
cell division, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU29610
Phenotypes of a mutant
- the ezrA mutation is synthetically lethal with a sepF mutation PubMed
- a yvcL ezrA double mutant grows poorly, and the cells are filamentous PubMed
- a zapA ezrA double mutant forms filamentous cells PubMed
- depletion of pdhA and deletion of ezrA have a strong synthetic defect in cell division PubMed
Database entries
- BsubCyc: BSU29610
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ezrA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
Database entries
- BsubCyc: BSU29610
- UniProt: O34894
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- constitutively expressed PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original Publications
