Difference between revisions of "ProA"
| Line 58: | Line 58: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13130&redirect=T BSU13130] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
| Line 95: | Line 96: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13130&redirect=T BSU13130] | ||
* '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1O20 1O20] (from ''Thermotoga maritima'', 46% identity, 67% similarity) {{PubMed|14705032}} | * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1O20 1O20] (from ''Thermotoga maritima'', 46% identity, 67% similarity) {{PubMed|14705032}} | ||
Revision as of 13:31, 2 April 2014
- Description: glutamate-5-semialdehyde dehydrogenase, required for normal and osmoadaptive proline biosynthesis
| Gene name | proA |
| Synonyms | |
| Essential | no |
| Product | glutamate-5-semialdehyde dehydrogenase |
| Function | biosynthesis of proline |
| Gene expression levels in SubtiExpress: proA | |
| Metabolic function and regulation of this protein in SubtiPathways: proA | |
| MW, pI | 45 kDa, 5.098 |
| Gene length, protein length | 1245 bp, 415 aa |
| Immediate neighbours | proB, ohrA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, coping with hyper-osmotic stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU13130
Phenotypes of a mutant
- auxotrophic for proline PubMed
Database entries
- BsubCyc: BSU13130
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH (according to Swiss-Prot)
- Protein family: gamma-glutamyl phosphate reductase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- BsubCyc: BSU13130
- UniProt: P39821
- KEGG entry: [2]
- E.C. number: 1.2.1.41
Additional information
Expression and regulation
- Regulatory mechanism:
- T-box: RNA switch, transcriptional antitermination PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
