LicA

• Description: lichenan-specific phosphotransferase system, EIIA component of the PTS
  
  

Gene name	licA
Synonyms	celC
Essential	no
Product	lichenan-specific phosphotransferase system, EIIA component
Function	lichenan uptake and phosphorylation
Gene expression levels in SubtiExpress: licA
Interactions involving this protein in SubtInteract: LicA
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	12 kDa, 4.641
Gene length, protein length	330 bp, 110 aa
Immediate neighbours	licH, licC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, phosphoproteins

This gene is a member of the following regulons

CcpA regulon, LicR regulon

The gene

Basic information

• Locus tag: BSU38570

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)

• Protein family: PTS permease, lactose permease (Lac) family PubMed

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • LicA-HPr, LicA-LicB

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 3K1S (IIA(Cel) from B. anthracis, 42% identity)

• UniProt: P46319

• KEGG entry: [2]

• E.C. number: 2.7.1.69

Expression and regulation

• Operon: licB-licC-licA-licH PubMed

• Expression browser: licA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • carbon catabolite repression (CcpA) PubMed
  • induction by oligomeric ß-glucosides (LicR)PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed
  • LicR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: