YwcE

• Description: holin, required for spore morphogenesis and germination
  
  

Gene name	ywcE
Synonyms	ipa-41r
Essential	no
Product	holin
Function	required for spore morphogenesis and germination
Gene expression levels in SubtiExpress: ywcE
MW, pI	9 kDa, 9.845
Gene length, protein length	261 bp, 87 aa
Immediate neighbours	rodA, qoxD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sporulation/ other, germination, membrane proteins

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU38130

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ywcE family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P39603

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ywcE PubMed

• Expression browser: ywcE PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during the log phase (AbrB), expressed only at the onset of stationary phase PubMed
  • strongly induced in response to glucose starvation in M9 medium PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Charles Moran, Emory University, NC, USA homepage