LmrA

• Description: transcriptional regulator, control of qdoI-yxaH and lmrA-lmrB
  
  

Gene name	lmrA
Synonyms	lin-2, yccB
Essential	no
Product	transcriptional regulator
Function	regulation of lincomycin resistance
Gene expression levels in SubtiExpress: lmrA
MW, pI	20 kDa, 5.033
Gene length, protein length	564 bp, 188 aa
Immediate neighbours	lmrB, ansZ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons

LmrA regulon

The LmrA regulon:

• lmrA-lmrB, qdoR, qdoI-yxaH

The gene

Basic information

• Locus tag: BSU02680

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): QdoR

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: flavonoids such as quercetin serve as inducers, binding results in release from DNA PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34619

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: lmrA-lmrB PubMed

• Expression browser: lmrA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by flavonoids such as quercetin (LmrA)PubMed

• Regulatory mechanism:
  • LmrA: transcription repression PubMed

• Additional information:
  • the mRNA is substantially stabilized upon depletion of RNase Y PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947