LiaF

• Description: inhibitor of LiaS kinase activity
  
  

Gene name	liaF
Synonyms	yvqF
Essential	no
Product	negative effector of LiaS
Function	control of LiaR activity
Gene expression levels in SubtiExpress: liaF
MW, pI	26 kDa, 9.211
Gene length, protein length	723 bp, 241 aa
Immediate neighbours	liaS, liaG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

LiaR regulon

The gene

Basic information

• Locus tag: BSU33100

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • inhibitor of LiaS kinase activity, maintains LiaS in the phosphatase state in the absence of the stress signal PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O32199

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • liaI-liaH-liaG-liaF-liaS-liaR PubMed
  • liaG-liaF-liaS-liaR PubMed

• Expression browser: liaF PubMed

• Sigma factor:
  • liaI: SigA PubMed
  • liaG: SigA PubMed

• Regulation:
  • liaI: induced by bacitracin and rhamnolipids (LiaR) PubMed
  • liaI: repressed during logarithmic growth (AbrB) PubMed, indirect regulation by AbrB PubMed
  • liaG: constitutive

• Regulatory mechanism:
  • LiaR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed