MetQ

• Description: methionine ABC transporter (binding lipoprotein)
  
  

Gene name	metQ
Synonyms	yusA
Essential	no
Product	methionine ABC transporter (binding lipoprotein)
Function	methionine uptake
Gene expression levels in SubtiExpress: metQ
Interactions involving this protein in SubtInteract: MetQ
Metabolic function and regulation of this protein in SubtiPathways: Cys, Met & Sulfate assimilation
MW, pI	30 kDa, 8.493
Gene length, protein length	822 bp, 274 aa
Immediate neighbours	yurZ, metP
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, biosynthesis/ acquisition of amino acids, membrane proteins

This gene is a member of the following regulons

CodY regulon, S-box

The gene

Basic information

• Locus tag: BSU32730

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): YhcJ

Extended information on the protein

• Kinetic information:
  • K(D) for Met: 3.8 myM PubMed

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • MetN-MetP-MetQ PubMed
  • McpC-MetQ, for chemotaxis to methionine PubMed

• Localization:
  • associated to the cell membrane, via MetP PubMed
  • extracellular (signal peptide) PubMed, lipid modification as retention signal

Database entries

• Structure:

• UniProt: O32167

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: metN-metP-metQ PubMed

• Expression browser: metQ PubMed

• Sigma factor:

• Regulation:
  • activated during growth in the presence of branched chain amino acids (CodY) PubMed
  • induced by methionine starvation (S-box) PubMed

• Regulatory mechanism:
  • S-box: transcription termination/ antitermination, the S-box riboswitch binds S-adenosylmethionine resulting in termination PubMed
  • CodY: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: