Difference between revisions of "DfrA"
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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of folate | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of folate | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21810 dfrA] |
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/DfrA DfrA] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/DfrA DfrA] | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ypkP]]'', ''[[thyB]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ypkP]]'', ''[[thyB]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU21810 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU21810 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU21810 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:dfrA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:dfrA_context.gif]] | ||
Revision as of 13:06, 13 May 2013
- Description: dihydrofolate reductase
| Gene name | dfrA |
| Synonyms | tmp |
| Essential | yes PubMed |
| Product | dihydrofolate reductase |
| Function | biosynthesis of folate |
| Gene expression levels in SubtiExpress: dfrA | |
| Interactions involving this protein in SubtInteract: DfrA | |
| Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation), Folate | |
| MW, pI | 19 kDa, 5.219 |
| Gene length, protein length | 504 bp, 168 aa |
| Immediate neighbours | ypkP, thyB |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
biosynthesis of cofactors, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU21810
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH (according to Swiss-Prot)
- Protein family: spmB family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 1ZDR (Geobacillus stearothermophilus)
- UniProt: P11045
- KEGG entry: [2]
- E.C. number: 1.5.1.3
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
