dfrA

dfrA
168

dihydrofolate reductase

Locus
BSU_21810
Molecular weight
19.03 kDa
Isoelectric point
5.22
Protein length
168 aaSequenceBlast
Gene length
507 bpSequenceBlast
Function
biosynthesis of folate
Product
dihydrofolate reductase
Essential
yes
E.C.
1.5.1.3
Synonyms
dfrA, tmp
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0262 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,296,603 → 2,297,109
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
(6S)-5,6,7,8-tetrahydrofolate + NADP+ --> 7,8-dihydrofolate + H+ + NADPH (according to UniProt)
Protein family
dihydrofolate reductase family (single member, according to UniProt)
Domains
DHFR domain (aa 1-159) (according to UniProt)
Structure
8UVZ (PDB) (complex with NADP+ and folate) PubMed
1ZDR (PDB) (Geobacillus stearothermophilus)
P11045 (AlphaFold)
Expression and Regulation
Operons
Genes
ypjP-ypjQ-thyB-dfrA-ypkP
Description
PubMed
Open in new tab

ypjP→ypkP

2025-03-12 11:48:47

Jstuelk

107

235b0d972d347f04b87f4c45ebac71a8a9d4b96a

9EB04D4A3A7698B00A36018A9A11CB02D30C8250

Genes
thyB-dfrA
Description
PubMed
Regulation
weak induction in the presence of glucose (CcpN) PubMed
Regulatory mechanism
CcpN: activation, weak, in ccpN regulon
Open in new tab

thyB→dfrA

2025-03-12 02:59:32

ghost

80

c85a29ba6a879af8f10ee961ab515c0e0a8b2658

B9BDE226BFA3A6A21A7E3540C80A424429DFA9B3

References
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B740E971204AC14BA456B8C93A86D4BDC29524FF

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Time of last update: 2025-03-10 20:04:56

Author of last update: Jstuelk