Difference between revisions of "FloA"
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|style="background:#ABCDEF;" align="center"|'''Function''' || resistance against sublancin | |style="background:#ABCDEF;" align="center"|'''Function''' || resistance against sublancin | ||
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| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/FloA FloA] | ||
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 35 kDa, 4.917 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 35 kDa, 4.917 | ||
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** a ''[[floT]] [[floA]]'' double mutant does not induce [[KinC]]-dependent biofilm formation upon addition of surfactin {{PubMed|20713508}} | ** a ''[[floT]] [[floA]]'' double mutant does not induce [[KinC]]-dependent biofilm formation upon addition of surfactin {{PubMed|20713508}} | ||
** a ''[[floT]] [[floA]]'' double mutant has a strong synthetic defect in motility, cell morphology, and transformation efficiency {{PubMed|22753055}} | ** a ''[[floT]] [[floA]]'' double mutant has a strong synthetic defect in motility, cell morphology, and transformation efficiency {{PubMed|22753055}} | ||
| + | ** a ''[[floT]] [[floA]]'' double mutant has a [[sporulation]] defect, due to the lack of [[FtsH]] {{PubMed|22882210}} | ||
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=== Database entries === | === Database entries === | ||
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=== Additional information=== | === Additional information=== | ||
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* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| + | ** [[FloA]]-[[FtsH]] {{PubMed|22882210}} | ||
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
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=References= | =References= | ||
'''Additional publications:''' {{PubMed|22178969}} | '''Additional publications:''' {{PubMed|22178969}} | ||
| − | <pubmed>16629676,11866510,18763711, 20713508 22753055</pubmed> | + | <pubmed>16629676,11866510,18763711, 20713508 22753055 22882210</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 10:25, 14 August 2012
- Description: flottilin-like protein (in addition to FloT), resistence protein (against sublancin), accessory role in resistance to cefuroxime
| Gene name | floA |
| Synonyms | yqfA |
| Essential | no |
| Product | flottilin-like protein |
| Function | resistance against sublancin |
| Interactions involving this protein in SubtInteract: FloA | |
| MW, pI | 35 kDa, 4.917 |
| Gene length, protein length | 993 bp, 331 aa |
| Immediate neighbours | yqfB, yqeZ |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
membrane dynamics, cell envelope stress proteins (controlled by SigM, V, W, X, Y), resistance against toxins/ antibiotics, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU25380
Phenotypes of a mutant
- a floT floA double mutant does not induce KinC-dependent biofilm formation upon addition of surfactin PubMed
- a floT floA double mutant has a strong synthetic defect in motility, cell morphology, and transformation efficiency PubMed
- a floT floA double mutant has a sporulation defect, due to the lack of FtsH PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: UPF0365 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P54466
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
