Difference between revisions of "LrpC"
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| − | + | * '''Description:''' sequence-independent DNA-binding and DNA-bending protein, facilitates the formation of higher order protein-DNA complexes <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair and recombination | |style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair and recombination | ||
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 7.743 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 7.743 | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:lrpC_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:lrpC_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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* '''Operon:''' ''lrpC'' {{PubMed|9341680}} | * '''Operon:''' ''lrpC'' {{PubMed|9341680}} | ||
| − | * | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|10913073}} |
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* '''Regulation:''' | * '''Regulation:''' | ||
Revision as of 11:17, 7 August 2012
- Description: sequence-independent DNA-binding and DNA-bending protein, facilitates the formation of higher order protein-DNA complexes
| Gene name | lrpC |
| Synonyms | ydaI |
| Essential | no |
| Product | DNA-binding and -bending protein |
| Function | DNA repair and recombination |
| MW, pI | 16 kDa, 7.743 |
| Gene length, protein length | 432 bp, 144 aa |
| Immediate neighbours | ydzA, topB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU04250
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 2CFX
- UniProt: P96582
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: lrpC PubMed
- Regulation:
- Regulatory mechanism:
- Additional information: 50 ... 300 molecules per cell PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Paul Thaw, Svetlana E Sedelnikova, Tatyana Muranova, Sebastian Wiese, Sylvia Ayora, Juan C Alonso, Arie B Brinkman, Jasper Akerboom, John van der Oost, John B Rafferty
Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family.
Nucleic Acids Res: 2006, 34(5);1439-49
[PubMed:16528101]
[WorldCat.org]
[DOI]
(I e)
Gema López-Torrejón, María I Martínez-Jiménez, Silvia Ayora
Role of LrpC from Bacillus subtilis in DNA transactions during DNA repair and recombination.
Nucleic Acids Res: 2006, 34(1);120-9
[PubMed:16407330]
[WorldCat.org]
[DOI]
(I e)
Christophe Beloin, Josette Jeusset, Bernard Revet, Gilles Mirambeau, Francoise Le Hégarat, Eric Le Cam
Contribution of DNA conformation and topology in right-handed DNA wrapping by the Bacillus subtilis LrpC protein.
J Biol Chem: 2003, 278(7);5333-42
[PubMed:12458218]
[WorldCat.org]
[DOI]
(P p)
C Beloin, R Exley, A L Mahé, M Zouine, S Cubasch, F Le Hégarat
Characterization of LrpC DNA-binding properties and regulation of Bacillus subtilis lrpC gene expression.
J Bacteriol: 2000, 182(16);4414-24
[PubMed:10913073]
[WorldCat.org]
[DOI]
(P p)
A Tapias, G López, S Ayora
Bacillus subtilis LrpC is a sequence-independent DNA-binding and DNA-bending protein which bridges DNA.
Nucleic Acids Res: 2000, 28(2);552-9
[PubMed:10606655]
[WorldCat.org]
[DOI]
(I p)
C Beloin, S Ayora, R Exley, L Hirschbein, N Ogasawara, Y Kasahara, J C Alonso, F L Hégarat
Characterization of an lrp-like (lrpC) gene from Bacillus subtilis.
Mol Gen Genet: 1997, 256(1);63-71
[PubMed:9341680]
[WorldCat.org]
[DOI]
(P p)
