Difference between revisions of "DisA"
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| − | + | * '''Description:''' DNA integrity scanning protein, delays sporulation in the case of chromosome damage, has diadenylate cyclase activity <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || control of sporulation initiation | |style="background:#ABCDEF;" align="center"|'''Function''' || control of sporulation initiation | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/DisA DisA] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/DisA DisA] | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:yacK_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:yacK_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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__TOC__ | __TOC__ | ||
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<br/><br/><br/><br/><br/><br/> | <br/><br/><br/><br/><br/><br/> | ||
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** ''disA'' [http://www.ncbi.nlm.nih.gov/sites/entrez/17434969 PubMed] | ** ''disA'' [http://www.ncbi.nlm.nih.gov/sites/entrez/17434969 PubMed] | ||
| − | * | + | * '''[[Sigma factor]]:''' |
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** ''[[ctsR]]'': [[SigA]] [http://www.ncbi.nlm.nih.gov/pubmed/8793870 PubMed], [[SigB]] [http://www.ncbi.nlm.nih.gov/pubmed/8793870 PubMed1] [http://www.ncbi.nlm.nih.gov/pubmed/11544224 PubMed2] | ** ''[[ctsR]]'': [[SigA]] [http://www.ncbi.nlm.nih.gov/pubmed/8793870 PubMed], [[SigB]] [http://www.ncbi.nlm.nih.gov/pubmed/8793870 PubMed1] [http://www.ncbi.nlm.nih.gov/pubmed/11544224 PubMed2] | ||
** ''disA'': [[SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17434969 PubMed] | ** ''disA'': [[SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17434969 PubMed] | ||
Revision as of 10:13, 7 August 2012
- Description: DNA integrity scanning protein, delays sporulation in the case of chromosome damage, has diadenylate cyclase activity
| Gene name | disA |
| Synonyms | yacK |
| Essential | no |
| Product | DNA integrity scanning protein, has diadenylate cyclase activity |
| Function | control of sporulation initiation |
| Interactions involving this protein in SubtInteract: DisA | |
| Metabolic function and regulation of this protein in SubtiPathways: Stress | |
| MW, pI | 40 kDa, 5.569 |
| Gene length, protein length | 1080 bp, 360 aa |
| Immediate neighbours | radA, yacL |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
cell division, metabolism of signalling nucleotides, sporulation/ other, general stress proteins (controlled by SigB), cell envelope stress proteins (controlled by SigM, V, W, X, Y), heat shock proteins
This gene is a member of the following regulons
CtsR regulon, SigB regulon, SigM regulon
The gene
Basic information
- Locus tag: BSU00880
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: synthesizes the small molecule cyclic diadenosine monophosphate (c-di-AMP) PubMed
- Protein family: disA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 3C23
- UniProt: P37573
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
