Difference between revisions of "RocR"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| − | {{SubtiWiki category|[[utilization of amino acids]]}}, | + | * {{SubtiWiki category|[[utilization of amino acids]]}}, |
{{SubtiWiki category|[[transcription factors and their control]]}} | {{SubtiWiki category|[[transcription factors and their control]]}} | ||
| + | * see also: [[glutamate metabolism]] | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
Revision as of 18:12, 3 June 2012
- Description: transcriptional activator of arginine utilization operons
| Gene name | rocR |
| Synonyms | |
| Essential | no |
| Product | transcriptional activator |
| Function | transcriptional activator of arginine utilization operons |
| Interactions involving this protein in SubtInteract: RocR | |
| Metabolic function and regulation of this protein in SubtiPathways: Ammonium/ glutamate | |
| MW, pI | 52.6 kDa, 6.08 |
| Gene length, protein length | 1383 bp, 461 amino acids |
| Immediate neighbours | rocD, yyxA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
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Contents
Categories containing this gene/protein
transcription factors and their control
- see also: glutamate metabolism
This gene is a member of the following regulons
The RocR regulon
The gene
Basic information
- Locus tag: BSU40350
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcription activation at SigL-dependent promoters of rocABC, rocDEF, and rocG
- Protein family: Sigma-54 interacting transcription activator
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Sigma-54 factor interaction domain (143–372)
- 2x nucleotid-binding domain (171–178),(233–242)
- HTH motif (434–453)
- Modification:
- Cofactor(s): ornithine or citrulline are required for RocR-dependent transcription activation PubMed
- Effectors of protein activity:
- Interactions:
- RocR-SigL
Database entries
- Structure:
- UniProt: P38022
- KEGG entry: [3]
Additional information
Expression and regulation
- Operon: rocR (according to DBTBS)
- Regulatory mechanism: autorepression
- Additional information:
Biological materials
- Mutant: QB5533 (aphA3), from Michel Debarbouille, available in Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- Antibody:
Labs working on this gene/protein
Michel Debarbouille, Pasteur Institute, Paris, France Homepage
Your additional remarks
References
