Difference between revisions of "ProH"
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|style="background:#ABCDEF;" align="center"| '''Product''' || pyrroline-5-carboxylate reductase | |style="background:#ABCDEF;" align="center"| '''Product''' || pyrroline-5-carboxylate reductase | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || osmoadaptive de novo production of proline |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/proline.html Pro], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/proline.html Pro], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | ||
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* '''Operon:''' ''[[proH]]-[[proJ]]'' {{PubMed|21296969}} | * '''Operon:''' ''[[proH]]-[[proJ]]'' {{PubMed|21296969}} | ||
| − | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|21784929}} |
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** expressed under conditions of osmotic stress | + | ** expressed under conditions of osmotic stress {{PubMed|21784929}} |
** induced by cold stress {{PubMed|21296969}} | ** induced by cold stress {{PubMed|21296969}} | ||
| Line 130: | Line 130: | ||
=References= | =References= | ||
| − | <pubmed>,11418582, 21296969</pubmed> | + | <pubmed> 21784929,11418582, 21296969</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 09:37, 26 July 2011
- Description: pyrroline-5-carboxylate reductase
| Gene name | proH |
| Synonyms | yoxE |
| Essential | no |
| Product | pyrroline-5-carboxylate reductase |
| Function | osmoadaptive de novo production of proline |
| Metabolic function and regulation of this protein in SubtiPathways: Pro, Stress | |
| MW, pI | 31 kDa, 7.754 |
| Gene length, protein length | 891 bp, 297 aa |
| Immediate neighbours | proJ, rtp |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, coping with hyper-osmotic stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU18480
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H (according to Swiss-Prot)
- Protein family: glutamate 5-kinase family (according to Swiss-Prot)
- Paralogous protein(s): ProI
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P14383
- KEGG entry: [2]
- E.C. number: 1.5.1.2
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
