Difference between revisions of "SinR"
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''Domains:''' |
| + | ** DNA-binding N-terminal domain (aa 1-69) {{PubMed|21708175}} | ||
| + | ** [[SinI]]-binding C-terminal domain (aa 74-111) {{PubMed|21708175}} | ||
* '''Modification:''' | * '''Modification:''' | ||
| Line 82: | Line 84: | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' [[SinI]] and [[SlrA]] are antagonists to [[SinR]] {{PubMed|19788541}} | + | * '''Effectors of protein activity:''' |
| + | ** [[SinI]] and [[SlrA]] are antagonists to [[SinR]] {{PubMed|19788541}} | ||
| + | ** [[SlrR]] is also antagonist of [[SinR]] {{PubMed|20351052}} | ||
| − | * '''Interactions:''' [[SlrA]]-[[SinR]] {{PubMed|19788541}} | + | * '''Interactions:''' |
| + | ** [[SlrA]]-[[SinR]] {{PubMed|19788541}} | ||
| + | ** [[SlrR]]-[[SinR]] {{PubMed|20351052}} | ||
| + | ** [[SinR]]-[[ScoC]] | ||
| + | ** [[SinR]]-[[SinI]] {{PubMed|9799632}} | ||
* '''Localization:''' | * '''Localization:''' | ||
| Line 90: | Line 98: | ||
=== Database entries === | === Database entries === | ||
| − | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1B0N 1B0N] (complex [[SinR]]-[[SinI]]) | + | * '''Structure:''' |
| + | ** [http://www.rcsb.org/pdb/explore.do?structureId=3QQ6 3QQ6] (N-terminal domain, aa 1-69) {{PubMed|21708175}} | ||
| + | ** [http://www.rcsb.org/pdb/explore.do?structureId=2YAL 2YAL] (C-terminal domain, aa 74-111) {{PubMed|21708175}} | ||
| + | ** [http://www.rcsb.org/pdb/explore.do?structureId=1B0N 1B0N] (complex [[SinR]]-[[SinI]]) {{PubMed|9799632}} | ||
* '''UniProt:''' [http://www.uniprot.org/uniprot/P06533 P06533] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P06533 P06533] | ||
Revision as of 21:23, 29 June 2011
- Description: transcriptional regulator of post-exponential-phase responses genes
| Gene name | sinR |
| Synonyms | sin, flaD |
| Essential | no |
| Product | transcriptional regulator of post-exponential-phase responses genes |
| Function | control of biofilm formation |
| Metabolic function and regulation of this protein in SubtiPathways: Biofilm, Central C-metabolism, Protein secretion | |
| MW, pI | 12 kDa, 7.177 |
| Gene length, protein length | 333 bp, 111 aa |
| Immediate neighbours | sinI, tasA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
transcription factors and their control, transition state regulators, biofilm formation
This gene is a member of the following regulons
AbrB regulon, ScoC regulon, Spo0A regulon
The SinR regulon
The gene
Basic information
- Locus tag: BSU24610
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcription repressor of biofilm genes, acts as co-repressor for SlrR PubMed
- Protein family:
- Paralogous protein(s): SlrR
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure:
- UniProt: P06533
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: TMB079 sinR::spec, GP736 (tetR), available in Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Stülke lab
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Patrick Piggot
Epigenetic switching: bacteria hedge bets about staying or moving.
Curr Biol: 2010, 20(11);R480-2
[PubMed:20541494]
[WorldCat.org]
[DOI]
(I p)
David Dubnau
Swim or chill: lifestyles of a bacillus.
Genes Dev: 2010, 24(8);735-7
[PubMed:20395361]
[WorldCat.org]
[DOI]
(I p)
Modelling of the SinI/SinR switch
Jennifer S Hallinan, Goksel Misirli, Anil Wipat
Evolutionary computation for the design of a stochastic switch for synthetic genetic circuits.
Annu Int Conf IEEE Eng Med Biol Soc: 2010, 2010;768-74
[PubMed:21095906]
[WorldCat.org]
[DOI]
(P p)
Original publications
Additonal publications: PubMed
