Difference between revisions of "McsB"
| Line 1: | Line 1: | ||
| − | * '''Description:''' protein arginine kinase, modulator of [[CtsR]]-dependent repression <br/><br/> | + | * '''Description:''' adaptor protein, protein arginine kinase, modulator of [[CtsR]]-dependent repression <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 60: | Line 60: | ||
=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
| − | |||
=The protein= | =The protein= | ||
| Line 81: | Line 78: | ||
* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' autophosphorylation {{PubMed|20852588}}, dephosphorylation by [[YwlE]] {{PubMed|20852588}} | + | * '''Modification:''' |
| + | ** autophosphorylation on specific arginine residues {{PubMed|20852588,21622759}}, dephosphorylation by [[YwlE]] {{PubMed|20852588,21622759}} | ||
| + | ** autophosphorylation stimulates McsB activity as adaptor protein for [[ClpC]] {{PubMed|21622759}} | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| Line 145: | Line 144: | ||
{{PubMed|19609260}} | {{PubMed|19609260}} | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed> 11179229,9987115, 8793870, 16497325,19226326, 9987115, 11544224, 20852588</pubmed> | + | <pubmed> 11179229,9987115, 8793870, 16497325,19226326, 9987115, 11544224, 20852588 21622759</pubmed> |
'''Additional publications:''' {{PubMed|17380125,16163393,19498169}} | '''Additional publications:''' {{PubMed|17380125,16163393,19498169}} | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 20:03, 10 June 2011
- Description: adaptor protein, protein arginine kinase, modulator of CtsR-dependent repression
| Gene name | mcsB |
| Synonyms | yacI |
| Essential | no |
| Product | protein arginine kinase |
| Function | control of CtsR activity |
| Metabolic function and regulation of this protein in SubtiPathways: Stress | |
| MW, pI | 40 kDa, 5.068 |
| Gene length, protein length | 1089 bp, 363 aa |
| Immediate neighbours | mcsA, clpC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
protein modification, transcription factors and their control, sporulation proteins, general stress proteins (controlled by SigB), heat shock proteins
This gene is a member of the following regulons
CtsR regulon, SigB regulon, SigF regulon
The gene
Basic information
- Locus tag: BSU00850
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: targets non-functional CtsR for degradation by ClpP/ClpC PubMed
- Protein family: ATP:guanido phosphotransferase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P37570
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original Publications
Additional publications: PubMed
