Difference between revisions of "Hbs"

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(Expression and regulation)
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
  
essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
+
essential {{PubMed|12682299,1382620}}
  
 
=== Database entries ===
 
=== Database entries ===
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=== Additional information===
 
=== Additional information===
 
 
  
  
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* '''Interactions:'''
 
* '''Interactions:'''
  
* '''Localization:''' cytoplasm (according to Swiss-Prot),  membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]  
+
* '''Localization:'''
 +
** associated with the nucleoid in vegetative cells and forespores {{PubMed|9068655,10715001}}
 +
** membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed]  
  
 
=== Database entries ===
 
=== Database entries ===
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<pubmed>11931565,</pubmed>
 
<pubmed>11931565,</pubmed>
 
==Original publications==
 
==Original publications==
<pubmed>1382620,1902464,10715001,9068655,9894920,16267290, 19458035, 19210617, 18763711, 17218307 </pubmed>
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<pubmed>1382620, 1902464,10715001,9068655,9894920,16267290, 19458035, 19210617, 18763711, 17218307 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 14:25, 4 May 2011

  • Description: non-specific DNA-binding protein Hbsu

Gene name hbs
Synonyms dbpA
Essential yes PubMed
Product non-specific DNA-binding protein Hbsu
Function DNA packaging, function of the signal recognition complex
MW, pI 9 kDa, 9.501
Gene length, protein length 276 bp, 92 aa
Immediate neighbours folE, spoIVA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Hbs context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

DNA condensation/ segregation, essential genes, membrane proteins, phosphoproteins

This gene is a member of the following regulons

LexA regulon, SigH regulon

The gene

Basic information

  • Locus tag: BSU22790

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: DbpA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on Thr-4 PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:
    • associated with the nucleoid in vegetative cells and forespores PubMed
    • membrane associated PubMed

Database entries

  • Structure: 1HUU (Geobacillus stearothermophilus)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:
    • mRNA is protected from degradation by RnjA by initiating ribosomes PubMed
    • Hbs is present with about 50,000 copies per genome in vegetative cells and spores, it is one of the most abundant proteins in B. subtilis PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Ciaran Condon, IBPC, Paris, France Homepage

Your additional remarks

References

Reviews

Original publications