GntR

• Description: transcriptional repressor of the gluconate operon
  
  

Gene name	gntR
Synonyms
Essential	no
Product	transcriptional repressor of the gluconate operon
Function	regulation of gluconate utilization
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	28 kDa, 5.26
Gene length, protein length	729 bp, 243 aa
Immediate neighbours	yxaA, gntK
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU40050

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: gluconate acts as molecular inducer

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P10585

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: gntR-gntK-gntP-gntZ PubMed1PubMed2

• Sigma factor: SigA PubMed

• Regulation:
  • induced by gluconate (GntR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • GntR: transcription repression PubMed
  • CcpA: transcription repression PubMed
  • AbrB: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: