Difference between revisions of "DapG"
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| − | + | * '''Description:''' aspartokinase I (alpha and beta subunits) <br/><br/> | |
| − | * '''Description:''' aspartokinase I (alpha and beta subunits) | ||
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of lysine and peptidoglycan | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of lysine and peptidoglycan | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/lys_threo.html Lys, Thr]''' |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 42 kDa, 5.709 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 42 kDa, 5.709 | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[asd]]'', ''[[dapA]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[asd]]'', ''[[dapA]]'' | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+& | + | |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB13549]+-newId sequences] <br/> (Barbe ''et al.'', 2009)''' |
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| − | |colspan="2" | '''Genetic context''' | + | |colspan="2" | '''Genetic context''' <br/> [[Image:dapG_context.gif]] |
| − | + | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | |
|- | |- | ||
|} | |} | ||
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__TOC__ | __TOC__ | ||
| − | + | <br/><br/><br/><br/><br/><br/> | |
=The gene= | =The gene= | ||
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=References= | =References= | ||
==Reviews== | ==Reviews== | ||
| − | + | <pubmed>19946135 ,, </pubmed> | |
==Original publications== | ==Original publications== | ||
| − | + | <pubmed>8345520,,15699190 8098035,2152900 , </pubmed> | |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 04:53, 24 November 2010
- Description: aspartokinase I (alpha and beta subunits)
| Gene name | dapG |
| Synonyms | lssD |
| Essential | no |
| Product | aspartokinase I (alpha and beta subunits) |
| Function | biosynthesis of lysine and peptidoglycan |
| Metabolic function and regulation of this protein in SubtiPathways: Lys, Thr | |
| MW, pI | 42 kDa, 5.709 |
| Gene length, protein length | 1212 bp, 404 aa |
| Immediate neighbours | asd, dapA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU16760
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + L-aspartate = ADP + 4-phospho-L-aspartate (according to Swiss-Prot)
- Protein family: aspartokinase family (according to Swiss-Prot)
- Paralogous protein(s): LysC
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: inhibited by diaminopimelic acid PubMed
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: Q04795
- KEGG entry: [3]
- E.C. number: 2.7.2.4
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Chien-Chi Lo, Carol A Bonner, Gary Xie, Mark D'Souza, Roy A Jensen
Cohesion group approach for evolutionary analysis of aspartokinase, an enzyme that feeds a branched network of many biochemical pathways.
Microbiol Mol Biol Rev: 2009, 73(4);594-651
[PubMed:19946135]
[WorldCat.org]
[DOI]
(I p)
Original publications
