Difference between revisions of "Phosphorelay"
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| + | |Parents= | ||
| + | * 3. [[Information processing]] | ||
| + | ** 3.4. [[Regulation of gene expression]] | ||
| + | |Neighbours= | ||
| + | * 3.4.1. [[Sigma factors and their control]] | ||
| + | * 3.4.2. [[Transcription factors and their control]] | ||
| + | * 3.4.3. [[Trigger enzymes]] | ||
| + | * 3.4.4. [[RNA binding regulators]] | ||
| + | * 3.4.5. [[Regulators of core metabolism]] | ||
| + | * 3.4.6. [[Transition state regulators]] | ||
| + | * 3.4.7. [[Phosphorelay]] | ||
| + | * 3.4.8. [[Quorum sensing]] | ||
| + | |Related= | ||
| + | none | ||
| + | |}} | ||
__TOC__ | __TOC__ | ||
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Revision as of 12:51, 12 November 2010
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Contents
The phosphorelay is a complex variation of a two-component regulatory system. It includes phosphotransferases that transfer the phosphoryl group from the sensor kinases to the ultimate target. The sporulation initiation phosphorelay is the paradigm of this class of signal transduction systems.
The kinases
The phosphotransferases
The ultimate target
Phosphatases controlling the phosphorelay (and peptides that modulate their activity)
- Spo0E: dephosphorylation of Spo0A
- YisI: dephosphorylation of Spo0A
- YnzD: dephosphorylation of Spo0A
- RapA, PhrA: dephosphorylation of Spo0F
- RapB: dephosphorylation of Spo0F
- RapE, PhrE: dephosphorylation of Spo0F
- RapH: dephosphorylation of Spo0F
A mathematical model
Reviews
Imke G de Jong, Jan-Willem Veening, Oscar P Kuipers
Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation.
J Bacteriol: 2010, 192(8);2053-67
[PubMed:20154131]
[WorldCat.org]
[DOI]
(I p)
Ruth E Silversmith
Auxiliary phosphatases in two-component signal transduction.
Curr Opin Microbiol: 2010, 13(2);177-83
[PubMed:20133180]
[WorldCat.org]
[DOI]
(I p)
Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21027-34
[PubMed:19995980]
[WorldCat.org]
[DOI]
(I p)
Daelynn R Buelow, Tracy L Raivio
Three (and more) component regulatory systems - auxiliary regulators of bacterial histidine kinases.
Mol Microbiol: 2010, 75(3);547-66
[PubMed:19943903]
[WorldCat.org]
[DOI]
(I p)
Keith Stephenson, James A Hoch
Evolution of signalling in the sporulation phosphorelay.
Mol Microbiol: 2002, 46(2);297-304
[PubMed:12406209]
[WorldCat.org]
[DOI]
(P p)
M Perego, J A Brannigan
Pentapeptide regulation of aspartyl-phosphate phosphatases.
Peptides: 2001, 22(10);1541-7
[PubMed:11587783]
[WorldCat.org]
[DOI]
(P p)
J A Hoch, K I Varughese
Keeping signals straight in phosphorelay signal transduction.
J Bacteriol: 2001, 183(17);4941-9
[PubMed:11489844]
[WorldCat.org]
[DOI]
(P p)
J A Hoch
Two-component and phosphorelay signal transduction.
Curr Opin Microbiol: 2000, 3(2);165-70
[PubMed:10745001]
[WorldCat.org]
[DOI]
(P p)
M Perego
Kinase-phosphatase competition regulates Bacillus subtilis development.
Trends Microbiol: 1998, 6(9);366-70
[PubMed:9778730]
[WorldCat.org]
[DOI]
(P p)
M Perego, P Glaser, J A Hoch
Aspartyl-phosphate phosphatases deactivate the response regulator components of the sporulation signal transduction system in Bacillus subtilis.
Mol Microbiol: 1996, 19(6);1151-7
[PubMed:8730857]
[WorldCat.org]
[DOI]
(P p)
J A Hoch
The phosphorelay signal transduction pathway in the initiation of Bacillus subtilis sporulation.
J Cell Biochem: 1993, 51(1);55-61
[PubMed:8432743]
[WorldCat.org]
[DOI]
(P p)
K Trach, D Burbulys, M Strauch, J J Wu, N Dhillon, R Jonas, C Hanstein, P Kallio, M Perego, T Bird
Control of the initiation of sporulation in Bacillus subtilis by a phosphorelay.
Res Microbiol: 1991, 142(7-8);815-23
[PubMed:1664534]
[WorldCat.org]
[DOI]
(P p)
