Difference between revisions of "LiaS"
(→The protein) |
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=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' | ||
| + | ** ''[[liaI]]-[[liaH]]-[[liaG]]-[[liaF]]-[[liaS]]-[[liaR]]'' {{PubMed|14651641}} | ||
| + | ** ''[[liaG]]-[[liaF]]-[[liaS]]-[[liaR]]'' {{PubMed|16816187}} | ||
| − | * ''' | + | * '''Sigma factor:''' |
| − | ''[[ | + | ** ''liaI'': [[SigA]] {{PubMed|15273097}} |
| + | ** ''liaG'': [[SigA]] {{PubMed|16816187}} | ||
| − | * ''' | + | * '''Regulation:''' |
| + | ** ''[[liaI]]'': induced by bacitracin ([[LiaR]]) {{PubMed|16816187}} | ||
| + | ** ''[[liaI]]'':repressed during logarithmic growth ([[AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed] | ||
| + | ** ''[[liaG]]'': constitutive | ||
| − | * ''' | + | * '''Regulatory mechanism:''' |
| − | ** | + | ** [[LiaR]]: transcription activation {{PubMed|16816187}} |
| − | |||
| − | |||
| − | |||
** [[AbrB]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed] | ** [[AbrB]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed] | ||
Revision as of 16:59, 28 December 2009
- Description: two-component sensor kinase, response to bacitracin
| Gene name | liaS |
| Synonyms | yvqE |
| Essential | no |
| Product | two-component sensor kinase |
| Function | control of LiaR activity in response to bacitracin |
| MW, pI | 40 kDa, 7.333 |
| Gene length, protein length | 1080 bp, 360 aa |
| Immediate neighbours | liaR, liaF |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU33090
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of LiaR
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain
- Modification: autophosphorylation on a His residue
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O32198
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
