Difference between revisions of "NifS"
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=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' ''[[nifS]]-[[yrxA]]'' {{PubMed|8444804}} | ||
| − | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|8444804}} | |
| − | |||
| − | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** repressed in the presence of nicotinic acid ([[NadR]]) | + | ** repressed in the presence of nicotinic acid ([[NadR]]) {{PubMed|8444804,16199587}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | ** [[NadR]]: transcription repression | + | ** [[NadR]]: transcription repression {{PubMed|8444804,16199587}} |
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 20:23, 26 November 2009
- Description: cysteine desulfurase, required for NAD biosynthesis
| Gene name | nifS |
| Synonyms | iscS |
| Essential | no |
| Product | cysteine desulfurase |
| Function | NAD biosynthesis |
| MW, pI | 43 kDa, 6.425 |
| Gene length, protein length | 1185 bp, 395 aa |
| Immediate neighbours | nadB, nadR |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU27880
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine (according to Swiss-Prot)
- Protein family: NifS/iscS subfamily (according to Swiss-Prot)
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P38033
- KEGG entry: [3]
- E.C. number: 2.8.1.7
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
